Shannon Larabee, a former student in the Special Masters Program in Physiology who is now an M3 here at GUMC recently published a paper as first author in Stem Cells and Development. The paper highlights how microRNAs function in early mammalian development to control critical intracellular signaling mechanisms important for the developmental stage called gastrulation. If gastrulation is not regulated properly by these miRNAs, differentiation of cells is impaired resulting in improper formation of organs. Shannon's tenacity and hard work really paid off with a really nice investigation, says Dr. G. Ian Gallicano, the senior author.
Larabee, S. M., H. Coia, S. Jones, E. Cheung, and G. I. Gallicano (2014, September). miRNA-17 Members that Target Bmpr2 Influence Signaling Mechanisms Important for Embryonic Stem Cell Differentiation In Vitro and Gastrulation in Embryos. Stem Cells and Development.